Grootfontein is a city in Otjozondjupa Region, Namibia. It lies on the B8, a Namibian National Road that leads from Windhoek to the Caprivi Strip, in the Otavi triangle. In Afrikaans, its name means "Big Spring" - there is indeed a large hot spring near the town.

Like all the towns in the Otavi triangle, Grootfontein is very green in summer but drier in winter. In spring, jacaranda and flamboyant trees bloom in profusion. The town has an old German Schutztruppe fortress from the year 1896, which today houses a museum that expounds on the local history. The economic mainspring of the area were for many decades the Berg Aukas and Abenab mines to the north east of the town.